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NNMT consumes S-adenosylmethionine (SAM) and methylates nicotinamide, depleting cellular methyl pools and downstream NAD+ precursors
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It enhances biochemical signaling for collagen and glycosaminoglycan production, recruits immune and endothelial cells to injury sites, and promotes remodeling of connective tissue
In human fibroblast cultures, this has been shown to extend the "Hayflick limit" (the number of times a cell can divide) by over 10 passages
