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disulfide linkers are known in the art, including but not limited to those that can be formed using SATA (N-succinimidyl-5-acetylthioacetate), SPDP (N-succinimidyl-3-(2-pyridyldi-thio)propionate), SPDB (N-succinimidyl-3-(2-pyridyldithio)butyrate) and SMPT (N-succinimidyl-oxycarbonyl-alpha-methyl-alpha-(2-pyridyl-dithio)tol-uene)

The FTO rs9939609 and MC4R rs17782313 variants relate to metabolic rate and appetite control, indirectly influencing cardiac workload during weight loss

Metabolic reprogramming and immune escape are considered to be the main characteristics of malignant tumors, which can be used to diagnose, detect and treat tumors [1, 2].In the past few decades, the Warburg effect has been considered as a typical example of metabolic reprogramming, wherein the tumor cells still rely on the conversion of glucose to lactate for energy needs under aerobic conditions, which is crucial for tumor initiation and progression [3, 4]

[DOI] [PubMed] [Google Scholar] 90.Yu E.Y., Li H., Higano C.S., Agarwal N., Pal S.K., Alva A., Heath E.I., Lam E.T., Gupta S., Lilly M.B., et al