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Note that in addition to canonical (barrier-related) functions, zonulin and occludin have other key, noncanonical functions that allow them namely to regulate epithelial apoptosis and proliferation and to facilitate viral entry (124)

For short-term storage, 2-8C (refrigerated) is acceptable

Cellbased therapies show promise in providing sustained motor amelioration, whereas microbiome interventions target nonmotor symptoms [274, 275]

187 Ongoing research continues to explore the efficacy of novel therapeutic interventions and the optimization of existing treatments to better manage these complex neuropathic conditions