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AMs are a type of tissue-resident macrophage, known for their potent phagocytosis and production of antimicrobials, TNF-, and nitric oxide (NO) against various pathogens

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For large-scale production, human iPSC-derived anti-CD19 CAR-M cells expanded in bioreactors exhibit specific phagocytic capacity against CD19 + leukemia cells, and single-cell sequencing confirms their ability to recruit adaptive immune cells through chemokine secretion (310)

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