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MRP (human multidrug resistance protein), a member of the superfamily of ATP-binding cassette membrane transporters, can confer resistance to multiple classes of chemotherapeutic agents (Kuo et al., 1998

Oxid Med Cell Longev (2018) 2018:9719584

With chronic excessive alcohol intake, damage to the liver occurs, which is also accompanied by chronic inflammation and oxidative stress

Although a higher lipophilicity should lead to an enhanced cellular uptake, as Pt(IV) complexes (unlike Pt(II) complexes) enter cells solely by passive diffusion, a lack of correlation between log P values and cellular Pt levels is not unprecedented 31,32

GPX4 knockdown had a similar effect on ferroptosis phenotypes as RSL3