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3.4 Risk of inducing stable resistance An additional critical concern when therapeutically exploiting DTP reversibility is the risk of unintentionally facilitating the transition of persister cells into genetically stable, irreversibly resistant populations (Mieras et al., 2016

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(1984) characterized structure-activity relationships in GHRH analogs, establishing that the first 29 amino acids contain the full biological activity and that specific substitutions can confer resistance to enzymatic degradation [1]

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