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Furthermore, 2-ME2 disrupts tubulin organization in HASMCs by binding to colchicine sites, thereby impeding mitosis and suppressing HIF-1 activity, which further inhibits cell proliferation [71, 77, 79, 80]

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(91) found that lens epithelial cells were extremely liable to ferroptosis evoked by erastin, a system Xc(-) inhibitor, or RSL3, a GPX4 inhibitor from studies conducted using in vitro lens epithelial cell and an ex vivo lens epithelial tissue

Even if a fibroid causes no pain or bleeding , it can affect fertility if it changes the shape of the uterine cavity the space where a pregnancy grows