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The stability of vitamin C in the gastrointestinal tract its bioavailability is limited

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This molecular explanation of ferroptotic cell death sets the stage for ferroptosis therapeutic strategies that not only act on lipid peroxidation, but that additionally target the executors of ferroptotic cell death: truncated PLs and LDEs

In addition, adipose tissue in the microenvironment is also capable of secreting IGF-1 to support microenvironmental remodeling (75)

Factors such as mitochondrial dysfunction, ERS, and oxidative stress play critical regulatory roles in this process, while the neuro-glial cell interaction network further exacerbates neuronal damage