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SastreJPallardoFVVinaJ.Mitochondrial oxidative stress plays a key role in aging and apoptosis

477 Consequently, the upregulation of ZIP7 is considered a significant feature of myocardial reperfusion injury and may present a novel therapeutic target for myocardial reperfusion injury and other cardiac diseases caused by oxidative stress or mitochondrial dysfunction

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Orhan C., Gencoglu H., Tuzcu M., Sahin N., Ojalvo S.P., Sylla S., Komorowski J.R., Sahin K

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM

For instance, many preclinical models administer sulforaphane simultaneously with an induced neuronal insult, creating an artificial scenario that may not reflect actual clinical applications