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Instruct patients to inform their healthcare providers if they are taking, or plan to take serotonergic medications (see PRECAUTIONS, Drug Interactions)

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While no evidence-based studies have evaluated their efficacy, digestive enzymes are often used for the purpose of aiding in digestion of proteins such as gluten and casein

With the onset of IDD, IVD, especially NP, undergoes a progressive dehydration due to proteolytic cleavage of aggrecan together (Karppinen et al., 2011), a substantial reduction of resident cell viability (Vergroesen et al., 2015)

Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, et al