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As the disease progresses, several symptoms affecting the legs may arise, including heaviness, aching, tiredness, itching, cramps, tingling, swelling, and pain

While gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) affect many patients initially, severe or persistent symptoms may necessitate dose adjustment, temporary dose reduction, or consideration of alternative therapies

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Always consult your healthcare provider before starting any medication

doi:10.1016/j.phrs.2019.104554 Talenezhad N, Mohammadi M, et al