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Nutrition, Well-Being and Health
Retrieved February 13, 2018
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174,175,176 Specifically, DKK1 has been reported to bind to LRP5/6, activate GSK-3, inhibit Wnt/-catenin signaling, and promote neuronal apoptosis by increasing the expression of the pro-apoptotic protein Bax and reducing the expression of the anti-apoptotic protein Bcl-2
