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Although the relationship between sleep and oxidative stress is still under intense investigation, several studies provide evidence that wakefulness represents an oxidative challenge for the brain (DAlmeida et al

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In brief, a high glucose environment induces a metabolic switch from fatty acid oxidation to glycolysis in renal proximal tubular epithelial cells (PTECs) [4, 18]

However, the GH/IGF-I axis in these disease states generally resets itself following the resolution of the inflammatory trigger (65)

doi: 10.1016/j.ejps.2014.04.004