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At supratherapeutic doses of APAP (more than 4 g/day), the sulfation pathway becomes saturated, while glucuronidation and oxidation increase, and a smaller amount is excreted unchanged

Remarkably, succinate has been shown to participate in wider metabolic processes through succinylation of key glycolytic enzymes including GAPDH, LDH, malate dehydrogenase and the glutamate carrier 1 (refs

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