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There was no significant difference in improvement of BFMDRS at 3 months (primary outcome) between the groups, except for a significant difference in improvement in the limb dystonia subscore, favoring the active stimulation group

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These pathways include the cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis 1,4 , the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q 10 (CoQ 10 ) axis on the plasma membrane 5,6 , the guanosine triphosphate cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) axis 7,8 , and the mitochondrial dihydroorotate dehydrogenase (DHODH)/CoQ system 9