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Clin Pharmacol Ther 2002;71:115

Although the pKa value of Cys-thiol GSH is relatively high (8.99.4) [3], indicating low reactivity in the intracellular environment, its central role in protecting cells from reactive oxygen/nitrogen species (RONS) is based on enzyme-catalyzed reactions, efficient recycling pathways, as well as the mass effect achieved by its high intracellular concentrations (210 mM)

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This dysfunction affects multiple organs, with respiratory failure being the most common, and cardiovascular failure often leading to the worst outcomes [69]

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