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GH altered the cytokine environment, triggered anti-inflammatory macrophage (M2) polarization, maintained activity of the suppressor T-cell population, and limited Th17 cell plasticity (49)

36 Current evidence suggests a possible link to depressive or suicidal ideation specific to semaglutide 37, and a clearly higher incidence of gastrointestinal adverse events compared with liraglutide.38 Both remain FDA-approved and well-studied

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K.SuleymanZ.SuleymanB.MammadovR.BulutS.AltunerD.et al (2024)

This means lower doses can achieve better results, with reduced berberine side effectsa crucial consideration for those with sensitive systems