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A key mechanism is the downregulation of MHC-I molecules mediated by the viral protein E5, which retains MHC-I within the Golgi and endoplasmic reticulum, reducing antigen presentation to CD8 + T cells and facilitating persistent infection (Miyauchi et al., 2023)

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The glutathione peroxidase ( GPX ) family represents one of the most important intracellular antioxidant enzyme systems, protecting cells from oxidative damage by reducing hydrogen peroxide and lipid hydroperoxides (2426)

Several mechanisms are possible, including pro-oxidant roles of certain enzymes in specific biochemical contexts (Johnston et al

These new papers open up a number of exciting avenues to see in which tissues and cells these hydropersufides normally function to block ferroptosis, and whether it is possible to augment the amounts of these sulfane sulfur species to treat degenerative diseases involving ferroptosis