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Lifelong voluntary aerobic exercise protocols have been shown to largely prevent age- and western diet-induced vascular endothelial dysfunction and arterial stiffening throughout the lifespan in mice, and this protective effect appears to be mediated by the mitigation of mitochondrial-derived oxidative stress and inflammation [116]

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Owing to the short life span and little energy associated with 3 Crt*, the oxidative damaging effects of these carotenoids are considered to be negligible [166]