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To test the possible increase in potency of the two drugs when given simultaneously, we injected a total volume of 4 ml of combined doses of L838,417 and CLP257 in a fixed dose ratio of \([{\mathrm{L 838,417]/[{\mathrm{CLP 257]\) = 1:55, given the relative EC50s of the two drugs calculated from the respective dose response curves with a priori assumption on the collapse at high doses of L838,417 (Fig

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Table 1 describes our predictions for the change in Glx/NAA and GABA/Glx ratios in ALS patients relative to healthy controls, based on the model presented in section Overview of MRS and Measurement of Glutamate, GABA, and Glutamine in the Presence of Neuronal Loss

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