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found that the expression of Prdx6 was regulated by specificity protein 1 (Sp1) at the transcriptional level, and the upregulation of Prdx6 could prevent podocyte impairment in DKD by alleviating oxidative stress and ferroptosis[84]

Collectively, the studies to date provide evidence that beetroot is an excellent source of antioxidants that protects cellular components from oxidation in vitro and importantly, in vivo

However, it can also be elevated in various benign conditions, rendering it ineffective for early detection or screening

In preclinical models of I/R injury, copper supplementation improves functional recovery by mitigating oxidative damage and enhancing mitochondrial bioenergetics [96]

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