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Conversely, ferroptosis inhibitors significantly attenuate 6-OHDA-induced neuronal damage (Chen et al, 2025c)

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This pathway may be specific to seeds inasmuch as leaves can accumulate large amounts of lysine without detectable LKR activity (Shaul and Galili, 1992)

doi: 10.1016/j.freeradbiomed.2008.04.010
Regarding iron metabolism, intracellular and extracellular ALDH2 decreases 4-HNE, activates the Nrf2/HO-1 pathway to decrease intracellular iron accumulation and mitigates hepatic cell ferroptosis through Parkin-mediated mitochondrial autophagy (131)
