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Description
When a patient comes to the hospital with an acetaminophen overdose, standard of care is to use intravenous NAC to protect the liver and help the body excrete accumulated toxins
L., Wohnsland F
What are the conclusions from clinical trials and meta-analyses
A pharmacologic strategy for overcoming limited NAC BBB permeability and/or active efflux out of the brain includes co-administration with the membrane transporter inhibitor probenecid, a classic and promiscuous ATP-binding cassette (ABC), and solute carrier (SLC) inhibitor that blocks transport of organic acids [6]
10.1038/s41590-020-0761-y Nat
