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Although the current evidence is very promising, there are still some knowledge gaps that should be addressed to further clarify the exact mechanisms linking NNMT to obesity and T2D and to develop clinical drugs targeting NNMT

An important role of GSSG in the NFB activating signal cascade is suggested by the facts that the potent NFB inducer, tetradecanoyl phorbol acetate, increases intracellular GSSG levels and GSSG/GSH ratios3

,, However, the translational potential of this technology is largely limited by a core factor: the performance and practical applicability of the matrix system

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