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Modulating proteostasis: peptidomimetic inhibitors and activators of protein folding

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A recent study showed an increase in Ca 2+ influx induced by TRPM3 agonist into TRPM3-positive ganglion cells in developing mice, whereas TRPM3 knockouts presented a reduction in these currents (Webster et al., 2020)

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The presence of catecholamines and relatively low concentration of antioxidant enzymes in the brain may make it susceptible to the harmful effects of oxidative stress which includes parameters such as superoxide dismutase (SOD), catalase (CAT), glutathione per-oxidase (GSH)

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Although variations were found among the lines with different mutations, quantitative reverse transcription (qRT)PCR measurement revealed a trend for reduced snRNAs of both major and minor classes in the patient-derived cells with the exception of R521G, which increased several snRNAs of the major class, particularly U4, accompanied by reduced snRNAs in the minor class (Fig

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