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Fumarate, or fumaric acid, is a naturally occurring organic acid that serves as a direct intermediate in the Krebs cycle (also known as the Citric Acid Cycle or TCA cycle)

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This method is utilized to measure AAs and carnitine/acetylcarnitines of type 2 diabetes patients, with results indicating that certain acetylcarnitine and AAs may be involved in the development of diabetic nephropathy

however these variants explained only a small percentage of the genetic variation of the disorders, further supporting the concept that epigenetic processes play an important role [17]

Stanley CA : Carnitine deficiency disorders in children