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Deficiency develops gradually, as the body stores approximately 2-5 mg of B12 in the liver, which can sustain normal function for several years even with inadequate intake or absorption

B., & Jacob, S

Long-term metformin use (the first-line type 2 diabetes drug) can lower B12 in a dose- and duration-dependent way: in the Diabetes Prevention Program Outcomes Study (Aroda and colleagues, The Journal of Clinical Endocrinology & Metabolism , 2016, roughly 1,700 participants), low B12 at 5 years occurred in 4.3 percent of metformin users versus 2.3 percent on placebo, and the gap widened with continued use

The complexity of T1D, characterized by a multifaceted interplay between genetics and the environment, presents persistent challenges to developing a preventive cure

[DOI] [PubMed] [Google Scholar] 40.Rosenbaum M, Goldsmith R, Bloomfield D
