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The addition of cisplatin to cyclophosphamide and doxorubicin (CAP) has been recently associated with overall response rates of 57% to 100% and complete response rates of 26% to 75% in small series of patients (Creagan, Woods et al., 1983;Alberts, Manning et al., 1981;Eisenberger, 1985)

Abbreviations WGCNA: Weighted gene co-expression network analysis ROS: Reactive oxygen species GEO: Gene expression omnibus AUC: Area under the curve ROC: Receiver operating characteristic GSH: Glutathione GSSG: Oxidized glutathione lncRNAs: Long non-coding RNAs miRNAs: MicroRNAs ceRNA: Competing endogenous RNA DSigDB: Drug signatures database MSigDB: Molecular signatures database CEJ: Cementoenamel junction ABC: Alveolar bone crest DCA: Decision curve analysis PDB: Protein data bank IHC: Immunohistochemistry References Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, et al

Recent advances in better understanding this condition have enabled us to construct a model for what the body looks like for people with CFS and the underlying mechanisms behind it progression

(Wu et al., 2016) developed an injectable functional hydrogel system manufactured by combining RADA16-I and RADA-KPSS (RADA-KPSS was manufactured by conjugating a bioactive motif derived from BMP-7 (KPSS) onto the C terminal of RADA16-I)

Nature 381 , 7780 (1996)