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Die Regeneration von Geweben und Organen frdern

Inflammopharmacology 31(1):115 Naik SR, Bharadwaj P, Dingelstad N, Kalyaanamoorthy S, Mandal SC, Ganesan A et al (2022) Structure-based virtual screening, molecular dynamics and binding affinity calculations of some potential phytocompounds against SARS-CoV-2

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Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, et al

For example, nano-PROTACs composed of a photosensitizer (protoporphyrin IX, PpIX) and a Src homology 2 domain-containing phosphatase 2 (SHP2)-targeting PROTAC peptide (aPRO) connected by a caspase-3 cleavable linker, among them aPRO is activated after phototherapy due to the increased expression of caspase-3 in tumor cells, inducing the targeted degradation of SHP2 through the ubiquitin-proteasome system, and the persistent depletion of SHP2 blocks the immunosuppressive checkpoint signaling pathways CD47/SIRP and PD-1/PD-L1 thereby reactivating anti-tumor macrophages and T cells (239)