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Upon oxidative stress or impaired autophagic clearance, the autophagy adaptor p62 (SQSTM1) accumulates and binds to Keap1 through its KIR domain, displacing Nrf2 and facilitating its stabilization and nuclear translocation

- ScienceDirect , N-acetyl Cysteine Administration Is Associated With Increased Cerebral Glucose Metabolism in Patients With Multiple Sclerosis: An Exploratory Study Glutathione and immune function - PubMed , Glutathione: A key player in autoimmunity - ScienceDirect , Health Benefits of Glutathione Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function - PMC The use of glutathione in canine itraconazole-associated hepatotoxicity | IDEALS How Does Glutathione Support Brain Health

These reactions are considered in more detail in Sulfur Oxidation of Components of the Mercapturate Pathway and Thiomethyl Shunt sections. Some cysteine S -conjugates formed in the bile may reenter liver cells to be converted therein to the corresponding mercapturate

Dipeptidase deficiency has been described in one patient

Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells