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A general sense of running on empty despite doing everything right

Furthermore, they resemble sympathetic neurons phenotype as they extend axons, are electrically excitable and respond to neurotransmitters 32,33

In response, the capillaries feeding the skin cells constrict, flushing out fluids and toxins and delivering them to the bloodstream to be eliminated

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Keywords: acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, porphyria cutanea tarda, hepatoerythropoietic porphyria Graphical Abstract Lay summary: Porphyrias are rare genetic disorders in which buildup of toxic by-products of heme synthesis, called porphyrins, accumulate in the body