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In mammalian liver cells, dimethylglycine and sarcosine, produced by choline oxidation, donate their methylene group to THF, through a process catalyzed by dimethylglycine dehydrogenase (DMGDH) and sarcosine dehydrogenase (SARDH), respectively [40]

10 In instances where thiopurine therapy is not tolerated, is contraindicated or, increasingly, is not preferred because of its increased risk of infections and certain malignancies, the use of advanced therapies for ongoing maintenance therapy following steroid induction is indicated

Case report: Aggressive progression of acute heart failure due to juvenile tuberculosis-associated Takayasu arteritis with aortic stenosis and thrombosis

Yoshino et al

From basic science research to clinical trials, the biomedical community has rapidly advanced toward a better understanding of ROS-metabolising systems and their contribution to specific conditions
