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Three authors (MM, AN, and JV) independently screened titles and abstracts following de-duplication

The difference between vial and pen storage primarily relates to air exposure: vials with unused doses can be re-capped and re-refrigerated between uses, while pens are single-use devices that must be discarded once opened, even if medication remains

The functional annotations for CCL11 were obtained from the UCSC Genome Browser 23

[1] [3] The standard UK treatment involves hydroxocobalamin 1mg intramuscular injections, with dosing regimens typically consisting of initial loading doses (e.g., every other day for two weeks) followed by maintenance doses every 2-3 months for conditions like pernicious anaemia

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