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Experimental evidence of -3 polyunsaturated fatty acid modulation of inflammatory cytokines and bioactive lipid mediators: their potential role in inflammatory, neurodegenerative, and neoplastic diseases

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This phenomenon of bidirectional imbalance provides the foundation for the model of SQOR as a metabolic rheostat. According to this model, SQORs primary physiological role is not simply to eliminate H 2 S, but to maintain H 2 S concentrations within an optimal steady-state windowand when this balance is lost in either direction, opposite pathological consequences ensue

Astrocytes mediate tonic GABA inhibition in several brain regions, including the thalamus and cerebellum 87,88 , and supply extracellular Cl to maintain inhibitory Cl currents 70