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H&E staining revealed that the atherosclerotic lesion areas in the aortic root cross-sections were significantly reduced in the HCD + ALC group compared with the HCD group (Figures 5D,E)

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For instance, glioblastoma (GBM), an angiogenic tumor type, releases TDEs containing high levels of miR-221, proteoglycans glypican-1, and syndecan-4, which promote the growth of endothelial cells and the development of tubules, thereby enhancing angiogenesis [29]