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Description
Considering that PSC activation is a key factor in pancreatic fibrosis, we speculated that excess ROS production induced by high glucose may induce PSC activation in vivo

Side effects are typically rare and mild, such as slight pain at the injection site or mild dizziness

It requires no injection, has excellent safety data, and is widely available

[6] Epidemiologic studies, including a large prospective cohort, have not conclusively shown an increase in birth defects from the use of topical tretinoin

Hence, caffeine has been a part of the human diet for many millennia and, if taken in moderation, is generally regarded as safe (GRAS)
