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It was revealed that at an early stage of the inflammatory reaction, the use of H 2 reduces the degree of infiltration of neutrophils and macrophages by inhibiting the expression of cell adhesion molecules (ICAM-1) and several chemokines (including MIP-1a and MIP-2) [84]

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Notably, polarized light microscopy revealed that treatment of primary hepatocytes and HepG2 cells with 250 M and 500 M NaOX, respectively, did not result in the formation of oxalate crystals, which were clearly visible in cells treated with 5 mM of NaOX (Extended Data Fig

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