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A Critical View on In Vitro Analysis of P-Glycoprotein (P-Gp) Transport Kinetics

International journal of cosmetic science , 27 (5), 271278

Study in mice [41, 42], rats [43], and in vitro [44] have shown that 2R,6R-HNK has a sustained antidepressant effect and alters long-lasting synaptic plasticity

So far, animal studies report no toxicity or major side effects , even at higher doses
