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OM & Ernhrung 124 (2008) F2 F21 2 Ariel Miller, Maya Korem, Ronit Almog, Yanina Galboiz, Vitamin B12, demyelination, remyelination and repair in multiple sclerosis, Journal of the Neurological Sciences, Volume 233, Issues 12, 15 June 2005, Pages 93-97, ISSN 0022-510X, 3 Reynolds EH, Bottiglieri TT, Laundy MM, Crellin RF, Kirker SC

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During exercise, skeletal muscle produces BDNF and releases lactate into the bloodstream, which crosses the blood-brain barrier and triggers additional BDNF expression in the brain