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MuSC Proliferation In aged skeletal muscle, NNMT overexpression is linked to impaired NAD+ salvage, dysregulated SIRT1 activity, and increased muscle stem cell (MuSC) senescence

The mechanism proceeds as follows: Mitochondrial Disruption: The KLAKLAK sequence disrupts the outer mitochondrial membrane, causing cytochrome c release and depolarizing the membrane potential

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