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Combined c-Met/Trk inhibition overcomes resistance to CDK4/6 inhibitors in glioblastoma

& Potschka, H

Oral glucose tolerance tests performed in clinical trials showed no significant changes in glucose handling, and fasting insulin levels remained stable throughout treatment periods
GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists

Just because something doesn't pull one specific lever doesn't mean it can't influence the entire machine
