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For research requiring minimal systemic effects, AOD9604 may be preferable

Annu Rev Nutr 1999;19:357-77

Heterozygous variation You have one copy of the MTHFR variation on either the 677 gene or the 1298 gene
We add 260mg of natural caffeine for extra pep, forgoing sugar & carbs that can lead to crashes, so the boost responds better

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