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COX8B, cytochrome c oxidase subunit 8B

We found that intracellular 1-MNA and NNMT protein expression levels were substantially higher in the fully differentiated adipocytes compared to the undifferentiated pre-adipocytes, which is consistent with the differentiation-dependent enhancement in NNMT mRNA levels and enzymatic activity reported previously in the 3T3-L1 cell lines.[37] The higher levels of 1-MNA and NNMT in adipocytes compared to pre-adipocytes may partially account for our observations that increasing concentrations (10 60 M) of NNMT inhibitor did not completely eliminate 1-MNA in adipocytes, but did fully suppress 1-MNA accumulation in undifferentiated pre-adipocytes

They typically demonstrate low absorption rates and limited plasma distribution and primarily undergo proteolytic metabolism characterized by amide bond cleavage in the backbone

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238 This complicates mechanistic interpretation and may lead to false-positive or irreproducible findings in high-throughput screening