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10.1093/advances/nmx009 Adv Nutr

The aim of this publication is to serve as a tutorial for conducting FIH trials for both small molecule and biological drug candidates with topics covering regulatory requirements, preclinical safety testing, study design considerations, safety monitoring, biomarker assessment, and global considerations

Topical numbing creams are usually applied before the procedure to minimize pain

As Barreto and colleagues discuss, individualizing the HD-MTX to provide both clinical effectiveness and safety is crucial, and the use of novel renal biomarkers may improve dose optimization

The prognostic value of circulating tumor DNA in Malignant melanoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis