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An excessive autoreaction in the SG of patients with SS or SjD leads to chronic inflammation in the local area

Its involved in a variety of metabolic functions that further contribute to energy production at the cellular level

During prolonged ER stress, misfolded or damaged proteins may be retro-translocated into the cytosol via the ER-associated degradation (ERAD) pathway, potentially overwhelming the proteasome 48

Zhang W, Bhandari S, Ding Y, Luo J, Feng B, Jiang Y, et al

Angiogenesis in Disease Dysregulation of angiogenesis occurs in various pathologies, and often this is caused or amplified by changes in the ECM