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The gut microbiome regulates the immune response of the lung microbiome through the production of metabolites, such as SCFAs, while the lung microbiome can also influence the development of intestinal diseases through alterations in the gut microbial community

The same group further reported significant increases in IL-17 from Th17 cells in mice with floxed Gpx4 alleles, suggesting that the proper homeostasis of GSH through Gpx4 specifically is relevant to the homeostasis of multiple T helper cell lineages

However, there is a limitation to the utility of LXR agonists as shown by the first generation synthetic LXR ligands which activate both LXRs and lead to marked increases in hepatic lipogenesis and plasma triglyceride levels

Janzer, R

Acta Virol