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A study evaluated the safety and efficacy of autologous bone marrow-derived mesenchymal stem cells (BM-D MSCs) (76), the results showed that treatment with BM-D MSCs slowed the disease progression in ALS patients with an inherently rapid disease course, However, due to the small size of this group, it wasnt possible to assess whether these changes were statistically significant

doi: 10.1016/B978-0-12-821751-1.00011-7 25 YeHRobakLAYuMCykowskiMShulmanJM

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These include dopamine-depleting agents, agonists and antagonists, deep brain stimulation, benzodiazepines, fetal cell transplantation, acetylcholinesterase inhibitors, glutamate antagonists, antiseizure prescriptions, lithium, and cannabinoids [94, 109, 110]

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