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Gastrointestinal side effects such as nausea, abdominal discomfort and/or diarrhea should be monitored closely

Double check if you are using the correct needle size and injection technique

The model suggests that this decrease is caused by the sequestration of Keap1 in the complex with Nrf2 due to its interaction with DEM

The latter in response to stimulation by intestinal microbial antigens, particularly LPS, upregulate the production of proinflammatory cytokines (e.g., IL-1, IL-6, TNF) and reactive oxygen species (ROS), contributing to the enhancement of pro-inflammatory reactions (Van Spaendonk et al., 2017)

doi: 10.1093/jnci/92.2.154