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Glycine may have a gastroprotective effect

Jandric I, Vrcic H, Jandric Balen M, et al

238 Vaillant-BeuchotL.MaryA.Pardossi-PiquardR.BourgeoisA.LauritzenI.EysertF.et al (2021)

In the IFIGENIA study, adding NAC 600 mg/day to prednisone and azathioprine slowed lung function decline and improved Diffusing Capacity of the Lung for Carbon Monoxide (DLCO), especially in early IPF ( The PANTHER trial (IPFnet) compared NAC, combination therapy (prednisone + azathioprine + NAC), and placebo in 236 patients ( Post hoc analysis revealed genotype-dependent response, with TOLLIP-TT carriers (25%) benefiting from NAC, no effect in TOLLIP-CT, and harm in TOLLIP-CC genotypes ( An RCT combining NAC with pirfenidone found no additional lung function benefit but increased photosensitivity ( 10.2 Summary of meta-analyses and reviews Systematic reviews and meta-analyses suggest that N-acetylcysteine modestly attenuates lung function decline (FVC, DLCO)

Vitamin B-12 injections for weight loss: Do they work