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The evidence base requires appropriate clinical trials, with additional endpoints including clinical symptoms of patients and additional biochemical parameters beyond plasma B12 levels alone before these alternative routes can be recommended with confidence in clinical guidelines

Store at 20C (standard freezer) in a dark, dry location

Don't compromise on the most fundamental variable in your entire experiment

It is not FDA-approved for human therapeutic use, and most evidence involves preclinical studies, animal models, and limited early human safety data

People who can't take in enough vitamin B12 are given this medicine